![]() ![]() None required hospitalization during the initial or reinfection episodes ( Table). Only 1 HCW had a concurrent condition (chronic bronchitis), and none were immunosuppressed. Signs and symptoms of reinfection lasted 9–23 days. Reinfection, confirmed by a nucleic acid amplification test using the GeneFinder COVID-19 Plus RealAmp Kit ( 3), developed 55–170 days after symptom onset of the first infection. After signs and symptoms resolved, the HCWs tested negative by qRT-PCR, Elecsys Anti-SARS-CoV-2 (Roche Diagnostics, ), or both. All 4 HCWs had mild COVID-19 signs and symptoms and recovered ( Table). We identified SARS-CoV-2 RNA in nasopharyngeal swab samples using real-time quantitative reverse transcription PCR (qRT-PCR) 2–4 days after symptom onset ( 2). For the initial infections, symptom onset ranged from April 5–May 10, 2020, and lasted 10–23 days. The 4 HCWs, consisting of 3 nurses and 1 staff member, were women with an average age of 44 years (range 40–61 years) (Figure 1, panel A). This study was approved by the Research Ethical Committee of the University of Campinas (approval no. We investigated 4 cases of SARS-CoV-2 reinfection among HCWs at the Hospital das Clínicas da Unicamp, a tertiary public hospital at the University of Campinas (Campinas, Brazil). Healthcare workers (HCWs) are consistently exposed to SARS-CoV-2 and are therefore susceptible to reinfection. ![]() The Pan American Health Organization provisionally defines reinfection as a positive SARS-CoV-2 test result >45 days after initial infection, given that other infections and prolonged shedding of SARS-CoV-2 or viral RNA have been ruled out ( 1). Whether the immune response elicited by an initial infection protects against reinfection is uncertain. As of April 8, 2021, COVID-19 has affected >132 million persons and caused >2.87 million deaths around the world ( ). Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, in late 2019. ![]()
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